Our work at the Yorkshire Laser Centre includes clinical trials of the effects of Photodynamic Therapy on different types of cancer. Some of the trials we have recently conducted include;

 

PDT Clinical studies

Indication

Title of study

 

No’s of patients recruited.

 

Lung Cancer

 

Study of the role of PDT in early central lung cancer: pilot study (K Moghissi YLC)

 

30

 

Photodetection

(for early lung cancer)

 

A pilot study of the accuracy of fluorescence bronchoscopy versus white light bronchoscopy in the detection of early bronchogenic cancer in high-risk individuals (K Moghissi YLC)

 

191

 

Oesophageal Cancer

 

Non-randomised comparison between endoscopic PDT and surgical resection in patients with early (stage I) oesophageal cancer (K Moghissi YLC)

 

80 (40 for each arm)

 

Oesophageal Cancer

 

Study to determine the place of endoscopic PDT within the range of treatment for oesophageal cancer. Matched pair subjects (K Moghissi YLC)

 

280 out of 1343 patients

 

 

Gynaecology

 

Study of the role of PDT in VIN: single or multiple PDT cycle (non-randomised prospective) – (C Gan Consultant Gynaecologist NLAG NHS Trust/YLC)

 

30 patients to date

 

Colo-rectal

 

Pilot study of the role of PDT in AIN in patients with or without HIV (G Duthie Dept of Academic Surgery/YLC)

 

26

 

Urology

 

Pilot study of the role of PDT in urothelial cancer ( L Coombs Consultant Urological Surgeon NLAG NHS Trust/YLC)

 

6 patients to date

Here at the Yorkshire Laser Centre we care about our patients and are aware that the knowledge of which options will help with your condition is key to decision making process and allowing you moving on with your life.

To help those that have been diagnosed with cancer we are happy to complete a thorough electronic review of your case notes to confirm if Photodynamic Therapy would help with your condition. As this is a premium service we do need to charge for the time this takes and the charge for this is £120.

If this is of interest to you please contact us and we can arrange for you to email your notes to us and supply the details for you to pay via Paypal.

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Concerns around so-called ‘next generation’ PDT and sonodynamic therapy

Photodynamic therapy (PDT) is a treatment option for some types of cancer that involves administration of a drug that is activated by light, usually from a laser. This causes cell death. The underlying scientific principles and numerous clinical studies have been published in peer-reviewed literature1 2 3.  PDT can be curative. For example, in non-melanoma skin cancers, PDT has less morbidity than cryotherapy and avoids the need for skin grafts in surgical excision of large lesions. Often it is palliative where it can bring welcome symptomatic relief and precious extra months’ quality life to the patient.

PDT has several key attractions: there is minimal loss of normal tissue; PDT can be repeated in the same area as often as required; it can be used after conventional treatments have failed or as a stand-alone treatment in appropriate patients.

There are clinics providing what is sometimes called Next Generation PDT (NGPDT) or sonodynamic therapy (SDT). In general, the treatments provided do not have the necessary scientific rigour that is expected. Often the light is delivered externally and it is claimed that this reaches the tumour but light penetration to internal cancers is insufficient for effective PDT. A critical appraisal of a clinical application of SDT has been published4. This concludes that there is no convincing data that shows that treatment carried out as reported is effective in the treatment of primary tumour and multiple metastases. Without critical safety and efficacy information, it is unjustifiable to test unproven unconventional techniques and substances in patients, particularly those in terminal stages.

PDT can be used effectively in the treatment and care of appropriate cancer patients

The use of so-called NGPDT or SDT cannot be recommended.

 

Prof Harry Moseley, Hon President British Medical Laser Association; Prof Sam Eljamel, Clinical Director Scottish PDT Centre; Prof Keyvan Moghissi, Clinical Director Yorkshire Laser Centre

 

References

1              Moghissi K, Dixon K, Stringer M et al. Photofrin PDT for early stage oesophageal cancer: Long term results in 40 patients and literature review. Photodiagnosis and Photodynamic Therapy 2009; 6: 159-66.

2              Allison RR, Sibata C, Gay H. PDT for cancers of the head and neck. Photodiagnosis and Photodynamic Therapy 2009; 6: 1-2.

3              Morton CA, McKenna KE, Rhodes LE et al. Guidelines for topical photodynamic therapy: update. British Journal of Dermatology 2008; 159: 1245-66.

4              Huang Z, Moseley H, Bown S. Rationale of Combined PDT and SDT Modalities for Treating Cancer Patients in Terminal Stage: The Proper Use of Photosensitizer. Integrative Cancer Therapies 2010; 9: 317-9.

ASSOCIATE SPECIALIST IN GENERAL SURGERY
Mr. M. Hemadri MBBS FRCS (Edin) MBA (Leics)


Associate Specialist in General Surgery, NLAG NHS FT
Fellow, NHS Institute for Innovation and Improvement (2008-09)
Honorary Clinical Tutor, Hull York Medical School
Member of SAS Committee, Royal College of Surgeons of England

Mr. Hemadri is a general surgeon; one of his special interests is day case and short stay surgery. He has played a significant part in introducing award winning services such as the single visit model for day case surgery and laser haemorrhoidectomy. These are notable innovations which have transformed the way patients are dealt with at Goole Hospital. He favours the use of local anaesthetic as the primary mode of anaesthesia wherever possible.

The improvements have resulted in our teams winning the local Health and Social Care Awards at Hull in 2008 for Service Transformation. Mr. Hemadri has held the Leaders for Change award from the Health Foundation in 2007 and has been noted as a "Hidden Hero of the NHS"™ by the BMA. He has considerable training and experience in clinical quality and patient safety improvement.

Laser Haemorrhoidectomy is a procedure done for large piles needing surgical removal (grade 3 or 4 haemorrhoids). It is done under simple local anaesthesia with additional mild to moderate sedation. After this procedure our patients are able to walk away within 2 hours. This procedure is an especial feature of Goole Hospital and Yorkshire Laser Centre.



CONSULTANT ANAESTHETIST
Dr. R. Sharawi MBBS, FFA, RCFI
R Sharawi

CONSULTANT GENERAL SURGEON
Mr. P. Moore MD FRCS
P. Moore

CONSULTANT SURGEON
Mr. G. Gregory BDS (MELB), LDS, FRACDS MBBS (MELB), FRCS (ED)
G. Gregory
Mr. A. Thorpe MD, FRCS (ED), FRCS (ENG), FETCS
A. Thorpe